| UNICEF Canada | Toronto Downtown |
| United Church of Canada - Simcoe Presbytery, Penetanguishene, Camp Simpresca | Penetanguishene |
| United Way Simcoe Muskoka | Midhurst |
| United Way Simcoe Muskoka, Simcoe County, Urgent Needs Fund | Springwater |
| United Way Simcoe Muskoka, Low-Income Energy Assistance Program (LEAP) | Simcoe County |
| Unknown Neighbours | |
| Uplift Black, Barrie | Barrie |
| Upper Canada Child Care, Alliston - Union Public School, Before and After School Child Care | Alliston |
| Upper Canada Child Care, Alliston - Boyne River Public School, Child Care Centre | Alliston |
| Upper Canada Child Care, Alliston - St Paul's Catholic School, Before and After School Child Care | Alliston |
| Upper Canada Child Care, Alliston - Wellington St E, Child Care Centre | Alliston |
| Upper Canada Child Care, Cookstown Central Public School, Before and After School Child Care | Cookstown |
| Upper Canada Child Care, Everett - Tosorontio Central Public School, Before and After School Child Care | Everett |
| Upper Canada Child Care, Innisfil - Lake Simcoe Public School, Before and After School Child Care | Innisfil |
| Upper Canada Child Care, Innisfil - Sunnybrae Elementary School, Before and After School Child Care | Innisfil |
| Uptown Boxing | Barrie |
| Urban Pantry Barrie, Barrie Good Food Box | Barrie |