| E3 Community Services, Alliston - Wellington St West, EarlyON Child and Family Centre | New Tecumseth |
| E3 Community Services, Angus - County Rd 10, EarlyON Child and Family Centre | Essa |
| E3 Community Services, Beeton, EarlyON Child and Family Centre | Beeton |
| E3 Community Services, Tottenham, EarlyON Child and Family Centre | New Tecumseth |
| EarlyON Child and Family Centre - Simcoe North, Midland, Emergency Baby Needs Depot | Midland |
| EarlyON Child and Family Centre - Simcoe North, Orillia - Colborne St, Emergency Baby Needs Depot | Orillia |
| Earth Day Canada | Toronto Downtown |
| Easter Seals Ontario, Barrie-Simcoe County Office | Barrie |
| Edenvale Classic Aircraft Foundation | Clearview (Simcoe County) |
| Ego's Berry Farm, Strawberry Picking | Oro-Medonte |
| Electrical Safety Authority | Mississauga |
| Elizabeth Fry Society Simcoe Muskoka | Barrie |
| Elizabeth Fry Society Simcoe Muskoka, Jail Visitation | Barrie |
| Elizabeth Fry Society Simcoe Muskoka, Student Placement | Barrie |
| Elizabeth Fry Society Simcoe Muskoka, Volunteer Program | Barrie |
| Elizabeth Fry Society Simcoe Muskoka, Youth Justice Committee / Extra Judicial Sanctions / Restorative Justice Circles | Barrie |
| Elizabeth Fry Society Simcoe Muskoka, Joyce Kope House | Barrie |
| Elmvale and District Food Bank, Elmvale & District Food Bank, Christmas Hamper Program | Springwater |
| Elmvale and District Food Bank, Elmvale & District Food Bank | Springwater |
| Empower Simcoe, Barrie - 40 Fraser Crt, Adult Day Services | Barrie |
| Empower Simcoe, Barrie - 40 Fraser Crt, Specialized Care - Children's Homes | Barrie |
| Empower Simcoe, Barrie - Inniswood Baptist Church Satellite, EarlyON Child and Family Centre | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Employment Support Services | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Family Home Program for Adults and Children | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Family Relief Program | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Family Support Program | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Group Homes | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Infant and Child Development Program | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Regional Housing Support Services | Barrie |
| Empower Simcoe, Barrie Head Office - 39 Fraser Crt, Youth Drop-in Program | Barrie |
| Empower Simcoe, Bradford, EarlyON Child and Family Centre | Bradford West Gwillimbury |
| Empower Simcoe, Innisfil, EarlyON Child and Family Centre | Innisfil |
| Empower Simcoe, Stroud, EarlyON Child and Family Centre | Innisfil |
| Envisage Pregnancy Services, Barrie | Barrie |
| Envisage Pregnancy Services, South Georgian Bay | Collingwood |
| Epilepsy Ontario [Central East] | Stouffville |
| Epilepsy Ontario [Central East], Stouffville, York Region Branch | Stouffville |
| ESS Direct Powered By Vertical | Barrie |
| Essa (Township of). Municipal Office | Essa |
| Essa (Township of). Municipal Office, No physical address, Rest Stations for Extreme Weather Relief | Essa |
| Essa and District Agricultural Society | Essa |
| Essa and District Agricultural Society, Essa Agriplex, Barrie Fair | Essa |
| Essa and District Agricultural Society, Essa Agriplex | Essa |
| Essa Historical Society | Essa |
| Essa Public Library, Angus Branch, Essa Public Library, Angus Branch | Essa |
| Essa Public Library, Thornton Branch, Essa Public Library, Thornton Branch | Essa |
| Essa Township Fire Department | Essa |
| Essential Staffing | Barrie |
| Ethnic Mosaic Alliance | Barrie |
| Eye Bank of Canada (The) - Ontario Division | Toronto Downtown Central |